Adlyxin, a new type 2 diabetes drug, is now available following approval by the FDA. It’s a once-a-day injection, used at mealtime, for adults with type 2 diabetes.
Adlyxin comes in a disposable pre-filled pen in a single dose of 20 micrograms. Patients will also receive a disposable pre-filled pen in a single dose of 10 micrograms that they should use once daily for their first 14 days. On day 15, patients will increase their dosage to 20 micrograms once a day.
Helps improve blood sugar levels
Adlyxin is a glucagon-like peptide-1 receptor agonist, a hormone that helps normalize blood sugar levels. The drug’s safety and effectiveness were evaluated in 10 clinical trials that enrolled 5,400 patients with type 2 diabetes. In these trials, Adlyxin was evaluated both as a standalone therapy and in combination with other FDA-approved diabetic medications, including metformin, sulfonylureas, pioglitazone and basal insulin. The FDA reports that Adlyxin improved hemoglobin A1c levels (a measure of blood sugar levels) in these trials.
In addition, more than 6,000 patients with type 2 diabetes at risk for atherosclerotic cardiovascular disease were treated with either Adlyxin or a placebo in a cardiovascular outcomes trial. Use of Adlyxin did not increase the risk of cardiovascular adverse events in these patients.
The FDA cautions that Adlyxin should not be used to treat people with type 1 diabetes or patients with increased ketones in their blood or urine (diabetic ketoacidosis).
Diabetes is a chronic condition that occurs when the body either does not properly produce, or use, the hormone insulin. Approximately 29 million Americans, and an estimated 415 million people worldwide, have diabetes. It’s believed that nearly 28 percent of Americans with diabetes—totaling 8 million people—are undiagnosed.
In the U.S., approximately 12 percent of those aged 20 and older have diabetes. Type 2 diabetes is the most common type, accounting for an estimated 90 to 95 percent of all diagnosed adult diabetes cases in the U.S. Type 1 diabetes is usually diagnosed in children and young adults. It used to be known as juvenile diabetes. Only about 5 percent of diabetes patients have this form of the disease.
adlyxinMore information about diabetes can be found on the web site of the American Diabetes Association.